Nicotinamide
mononucleotide ("NMN",
"NAMN", and "β-NMN") is a nucleotide derived from ribose and nicotinamide. Like nicotinamide
riboside (NR), NMN is a
derivative of niacin
NMN is a precursor to NAD+, or nicotinamide adenine
dinucleotide, meaning it becomes NAD+ through a series of chemical
transformations. NAD+ is a critical compound found in every cell of your body,
but levels of NAD+ naturally fall with age, making it — and NMN, as a result —
crucial.
NAD+ is vital to cellular metabolism, turning
nutrients into cellular energy, and it also activates sirtuins, a set of
proteins that regulate cellular health. We all get NAD+ in our bodies thanks to
our diet, by consuming foods with NAD+ precursors in them. While NR and NMN can
be found in trace amounts in various foods, though, one can’t eat enough of
anything to boost NAD+ levels. As a result, supplementing with an NAD+
precursor can help mitigate the decline.
Animal studies showed that supplementing NR and NMN
could provide other myriad benefits as a result of boosting NAD+.
However, despite the theory that NMN could be
highly beneficial to cellular metabolism, an obstacle tends to stand in the way
of its utility in the human cell: it does not enter the cell easily and this is
attributable to the fact that it is so large. One way for NMN to enter the cell
is for it to chemically transform into another molecule (called nicotinamide riboside, or NR) before it can enter
the cell. When NMN becomes NR and enters the cell, it transforms back to NMN
and then ultimately becomes NAD+ which is then utilized by the cell
Sirtuins help
regulate cellular health and play a role in cellular aging.
One of the greatest
authorities in the field of genetics and the biology of aging is Dr David A. Sinclair Ph.D., A.O.
Dr
Sinclair is
a Professor in the Department of Genetics and co-Director of the Paul F. Glenn
Center for the Biology of Aging at Harvard Medical School. He is best known for
his work on understanding why we age and how to slow its effects. He
obtained his Ph.D. in Molecular Genetics at the University of New South Wales,
Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr.
Leonard Guarente where he co discovered a cause of aging for yeast as well as
the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he
was recruited to Harvard Medical School where he has been teaching aging
biology and translational medicine for aging for the past 16 years. His
research has been primarily focused on the sirtuins, protein-modifying enzymes that
respond to changing NAD+ levels and to caloric restriction (CR) with associated
interests in chromatin, energy metabolism, mitochondria, learning and memory,
neurodegeneration, and cancer. The Sinclair lab was the first one to identify a
role for NAD+ biosynthesis in regulation of lifespan and first showed that
sirtuins are involved in CR in mammals. They first identified small molecules
that activate SIRT1 such as resveratrol and studied how they improve metabolic
function using a combination of genetic, enzymological, biophysical and
pharmacological approaches. They recently showed that natural and synthetic
activators require SIRT1 to mediate the in vivo effects
in muscle and identified a structured activation domain. They demonstrated that
miscommunication between the mitochondrial and nuclear genomes is a cause of
age-related physiological decline and that relocalization of chromatin factors
in response to DNA breaks may be a cause of aging.
Dr.
Sinclair is co-founder of several biotechnology companies (Sirtris, Ovascience,
Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the
boards of several others. He is also co-founder and co-chief editor of the
journal Aging. His work is
featured in five books, two documentary movies, 60 Minutes, Morgan Freeman’s
“Through the Wormhole” and other media. He is an inventor on
35 patents and has received more than 25 awards and honors including the
CSL Prize, The Australian Commonwealth Prize, Thompson Prize, Helen
Hay Whitney Postdoctoral Award, Charles Hood Fellowship, Leukemia Society
Fellowship, Ludwig Scholarship, Harvard-Armenise Fellowship, American
Association for Aging Research Fellowship, Nathan Shock Award from the
National Institutes of Health, Ellison Medical Foundation Junior and
Senior Scholar Awards, Merck Prize, Genzyme Outstanding Achievement in
Biomedical Science Award, Bio-Innovator Award, David Murdock-Dole
Lectureship, Fisher Honorary Lectureship, Les Lazarus
Lectureship, Australian Medical Research Medal, The Frontiers in
Aging and Regeneration Award, Top 100 Australian Innovators, and TIME
magazine’s list of the “100 most influential people in the world”.
NMN is a SUPER COENZYME that is specifically
created to:
Act as an anti-aging product by repairing broken DNA strands.
Act as SIRTUIN Activator – It is required for activating
human longevity genes to work in promoting long life.
Act as brain and heart tonic – prevents dementia; activates
blood vessels and muscles.
Prevent and treat diabetes.
Boost energy metabolism – NMN helps to breakdown foods like
sugars into energy.
Looking to turn back the hands of time and feel young again?
Go for BF SUMA’s NMN. Testimonials here cannot be duplicated
anywhere else!
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